TOLBUTAMIDE HYPOGLYCEMIA IN ACUTELY DEPANCREATIZED DOGS*†
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چکیده
منابع مشابه
Tolbutamide hypoglycemia in acutely depancreatized dogs.
The hypoglycemic activity of tolbutamide and related compounds is well established; however, their mode of action is still debated. Several theories have been postulated (1-5). One of the most widely held is that tolbutamide stimulates the beta cells of the pancreas and the resulting insulin secretion produces the fall in blood sugar (1). The reported ineffectiveness of tolbutamide in depancrea...
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Human diabetics on intermediate and long-acting insulin occasionaly become hypoglycemic during exercise. We have shown previously that during exercise, hypoglycemia did not occur in depancreatized insulin-infused dogs because the increments in glucose production and utilization were proportional and of the same magnitude as in normal dogs. Therefore, to elucidate the mechanism of the glucose-lo...
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The intravenous Na-tolbutamide test was done on various types of hypoglyce mia and the following conclusions were obtained: (1) Though very useful in the screening of hypoglycemia, the test is not always satisfactory for the differential diagnosis of various types of hypoglycemia. (2) The diagnosis of hypoglycemia by means of the Na-tolbutamide test is con sidered practically established when t...
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In normal human subjects the administration of glucose produces an increase in blood pyruvic acid (l-3). In patients with diabetes mellitus the rise in blood pyruvate under the same conditions is either delayed and smaller or does not occur at all (2, 4). Insulin, administered to diabetic patients either simultaneously with glucose or several hours after glucose ingestion, produces a marked inc...
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Armstrong, S. H. jun. (1950). Re8earch in Medical Science. New York: Macmillan Co. Cremer, H. D. & Tiselius, A. (1950). Biochem. Z. 320, 273. Crook, E. M., Harris, H. & Warren, F. L. (1952). Biochem. J. 51, xxvi. Durrum, E. L. (1950). J. Amer. chem. Soc. 72, 2943. Flynn, F. V. & de Mayo, P. (1951). Lancet, 2, 235. Grassman, W., Hannig, K. & Knedel, M. (1951). Deut8ch. med. Wschr. 76, 333. Kunke...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1959
ISSN: 0021-9738
DOI: 10.1172/jci103872